There are two ways of searching the database:

Gene-centric:
which cancertypes (and subtypes) are reported as being methylated in the genes that are searched?
> browse through genes

	Browse through the genes in PubMeth: select a gene and discover in which cancer types it is described as methylated. Then continue browsing to see the full details for the chosen gene in a certain cancertype.
	Fast browsing as everything is precomputed, simply browse to discover
	No summarised overview of the genes of your interest, user could get lost in too much (levels of) information

> start a gene-centric search

	Specify the genes of your interest, check if they are present in PubMeth and get a summarized overview with only the genes you selected
	Strong focus: only the genes of interest are included; summarisation views are good guides
	Not as fast as browsing as created on the fly

Cancer-centric:
which genes are reported as being methylated in certain cancer types / cancer subtypes?
> start a cancer-centric search (select from all available cancer types)

	Specify the cancer (sub)types of your interest, see differences within one main cancertype or between different types
	Strong focus: only the cancer (sub) types of interest are included; summarisation views are good guides; linked with gene-centric browsing for fast switching cancer-gene
	Not as fast as gene-centric browsing; detailed views don't group subtypes; all cancer types are listed, need to scroll to find intersting cancertypes

> start a cancer-centric search (only list cancertypes, based on user search)

	Search for cancer types or subtypes, see which are included in PubMeth and query PubMeth with selected cancertypes
	Strong focus: only the cancer (sub) types of interest are included; summarisation views are good guides; linked with gene-centric browsing for fast switching cancer-gene ;only lists cancer types that the user has searched for
	Not as fast as gene-centric browsing; detailed views don't group subtypes ; nomenclature: cancer type or subtype may be called different in PubMeth

Combined:
Combined search: see which genes of your interest are methylated in the cancer (sub)types of interest
> start combined (gene-cancer) search