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There are two ways of searching the database:
Gene-centric:
which cancertypes (and subtypes) are reported as being methylated in the genes that are searched?
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Browse through the genes in PubMeth: select a gene and discover in which cancer types it is described as methylated. Then continue browsing to see the full details for the chosen gene in a certain cancertype. |
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Fast browsing as everything is precomputed, simply browse to discover |
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No summarised overview of the genes of your interest, user could get lost in too much (levels of) information |
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Specify the genes of your interest, check if they are present in PubMeth and get a summarized overview with only the genes you selected |
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Strong focus: only the genes of interest are included; summarisation views are good guides |
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Not as fast as browsing as created on the fly |
Cancer-centric:
which genes are reported as being methylated in certain cancer types / cancer subtypes?
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Specify the cancer (sub)types of your interest, see differences within one main cancertype or between different types |
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Strong focus: only the cancer (sub) types of interest are included; summarisation views are good guides; linked with gene-centric browsing for fast switching cancer-gene |
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Not as fast as gene-centric browsing; detailed views don't group subtypes; all cancer types are listed, need to scroll to find intersting cancertypes
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Search for cancer types or subtypes, see which are included in PubMeth and query PubMeth with selected cancertypes |
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Strong focus: only the cancer (sub) types of interest are included; summarisation views are good guides; linked with gene-centric browsing for fast switching cancer-gene ;only lists cancer types that the user has searched for |
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Not as fast as gene-centric browsing; detailed views don't group subtypes ; nomenclature: cancer type or subtype may be called different in PubMeth |
Combined:
Combined search: see which genes of your interest are methylated in the cancer (sub)types of interest
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